Which therapy is used after renal biopsy confirms FSGS?

• A. Prednisone therapy
• B. ACE inhibitors
• C. Diuretics
• D. Anticoagulation

Answer: (A)

Corticosteroids are used as first-line therapy for primary FSGS after biopsy confirmation. Prednisone helps suppress immune-mediated injury to the glomeruli, which reduces proteinuria and can preserve kidney function in many patients. While ACE inhibitors or ARBs are important to lower proteinuria and protect renal function, they address symptoms and hemodynamics rather than the underlying disease. Diuretics relieve edema, and anticoagulation is reserved for nephrotic syndrome complications like thrombosis, not as a treatment for the glomerular disease itself.