VWD usually presents with irregular menses. Is this statement true or false?

• A. False
• B. True
• C. Depends on severity
• D. Not enough information

Answer: (A)

VWD is a bleeding disorder where deficiency or dysfunction of von Willebrand factor impairs platelet adhesion and stabilizes factor VIII, leading to a tendency for mucosal bleeding. In women, the most characteristic clue is heavy or prolonged menstrual bleeding (menorrhagia), not irregular menstrual cycles. While cycles can vary for many reasons, the hallmark presentation in VWD is excessive menstrual bleeding, which can cause anemia. Therefore the statement that irregular menses are the usual presentation is not correct.