Cephalosporins have no role in treating Chlamydia.

• A. True
• B. False
• C. Not applicable
• D. Sometimes

Answer: (A)

Chlamydia trachomatis is an obligate intracellular organism with a limited peptidoglycan layer, so beta-lactam antibiotics like cephalosporins, which inhibit cell wall synthesis, have little to no effect on it. Effective treatment relies on agents that reach and act within host cells, such as doxycycline or azithromycin. Cephalosporins do have a role against gonorrhea, so in cases of suspected co-infection you might use a cephalosporin to cover Neisseria gonorrhoeae along with doxycycline or azithromycin to cover Chlamydia. But cephalosporins alone do not treat Chlamydia, so the statement is true.